INHIBITOR AGAINST OPIOID HYDROLYZING ENZYME

NEW MATERIAL:An organogermanium compound expressed by formula I [R1 is lower alkyl; R2-R4 are H, lower alkyl or (substituted) phenyl; Z is carboxyl, benzylaminomethyl or hydrochloride thereof]. EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of...

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Hauptverfasser:	YOSHIHARA TORU, KAKIMOTO NORIHIRO, HASATO TADAHIKO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:An organogermanium compound expressed by formula I [R1 is lower alkyl; R2-R4 are H, lower alkyl or (substituted) phenyl; Z is carboxyl, benzylaminomethyl or hydrochloride thereof]. EXAMPLE:(n-C3H7)GeCH2CH2COOH. USE:An inhibitor against opioid hydrolyzing enzymes and analgesi capable of selectively inhibiting enzymes hydrolyzing enkephalin which is one kind of endogenous morphinic substance, e.g. aminopeptidase derived from simian brains, etc., in a low concentration. PREPARATION:For example, trichlorogermylpropionic acid expressed by formula III is reacted with a Grignard reagent expressed by the formula R1MgX in a solvent e.g. ethyl ether, etc., while heating and refluxing according to the reaction formula and the resultant product is then hydrolyzed with hydrochloric acid.