1,2-SUBSTITUTED ERGOLINE DERIVATIVE, MANUFACTURE AND SCHIZOPHRENIA AND DEPRESSION REMEDY

The disclosure relates to 1,2-substituted ergoline derivatives of general Formula I (I) wherein X is an oxygen or sulfur atom, R1 is a lower alkyl group, R2 is halogen, acyl, a saturated or unsaturated lower alkyl group which can optionally be substituted by OR4 wherein R4 is hydrogen, lower alkyl, tetrahydropyranyl or cycloalkyl, or by an optionally substituted aryl residue, an S-R5-group wherein R5 means a lower alkyl group which can optionally be substituted by aryl or an optionally substituted aryl residue, a wherein n=2 o4 3, or a -CHO-group, R3 is lower alkyl or acyl, and C9-C10 is a CC-single or a CC-double bond, and the hydrogen atom in the 10-position is in the alpha -location if C9-C10 is a CC-single bond, as well as the acid addition salts thereof. The compounds exhibit valuable pharmacological properties.