4-AMINOPYRIDINAMIDE DERIVATIVE
NEW MATERIAL:The compound of formula I [R is H, halogen or lower alkoxy; R' is H or lower alkoxy; n is 1 or 2; when n is 2, two R groups may be the same or different; the position of R is 2'', 3'', 4'', 5'' or 6'' or an arbitrary combination the...
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| creator | SAKAKIBARA KAZUMASA YONESHIMA NOBUYASU OSAWA TATESHI |
| description | NEW MATERIAL:The compound of formula I [R is H, halogen or lower alkoxy; R' is H or lower alkoxy; n is 1 or 2; when n is 2, two R groups may be the same or different; the position of R is 2'', 3'', 4'', 5'' or 6'' or an arbitrary combination thereof]. EXAMPLE:N-[4'-(2''-chorobenzyloxy)-3'-methoxybenzoyl]-4-aminopyridine. USE:It has activity to promote myocardial contraction and is useful as a remedy for congestive cardiac insufficiency and a cardiotonic agent. PREPARATION:The compound of formula I can be produced by reacting an acid halide of formula II (X is Cl or Br) with 4-aminopyridine in the presence of a base (e.g. triethylamine). |
| format | Patent |
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EXAMPLE:N-[4'-(2''-chorobenzyloxy)-3'-methoxybenzoyl]-4-aminopyridine. USE:It has activity to promote myocardial contraction and is useful as a remedy for congestive cardiac insufficiency and a cardiotonic agent. PREPARATION:The compound of formula I can be produced by reacting an acid halide of formula II (X is Cl or Br) with 4-aminopyridine in the presence of a base (e.g. triethylamine).</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870714&DB=EPODOC&CC=JP&NR=S62158253A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870714&DB=EPODOC&CC=JP&NR=S62158253A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SAKAKIBARA KAZUMASA</creatorcontrib><creatorcontrib>YONESHIMA NOBUYASU</creatorcontrib><creatorcontrib>OSAWA TATESHI</creatorcontrib><title>4-AMINOPYRIDINAMIDE DERIVATIVE</title><description>NEW MATERIAL:The compound of formula I [R is H, halogen or lower alkoxy; R' is H or lower alkoxy; n is 1 or 2; when n is 2, two R groups may be the same or different; the position of R is 2'', 3'', 4'', 5'' or 6'' or an arbitrary combination thereof]. EXAMPLE:N-[4'-(2''-chorobenzyloxy)-3'-methoxybenzoyl]-4-aminopyridine. USE:It has activity to promote myocardial contraction and is useful as a remedy for congestive cardiac insufficiency and a cardiotonic agent. 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EXAMPLE:N-[4'-(2''-chorobenzyloxy)-3'-methoxybenzoyl]-4-aminopyridine. USE:It has activity to promote myocardial contraction and is useful as a remedy for congestive cardiac insufficiency and a cardiotonic agent. PREPARATION:The compound of formula I can be produced by reacting an acid halide of formula II (X is Cl or Br) with 4-aminopyridine in the presence of a base (e.g. triethylamine).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 4-AMINOPYRIDINAMIDE DERIVATIVE |
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