13-METHYL-13-DIHYDRO-4-DEMETHOXYDAUNOMYCINONE DERIVATIVE

13-METHYL-13-DIHYDRO-4-DEMETHOXYDAUNOMYCINONE DERIVATIVE

NEW MATERIAL:The 13-methyl-13-dihydro-4-demethoxydaunomycin derivative of formula I (R is H or trialkylsilyl). EXAMPLE:13-Methyl-13-dihydro-7-O-t-butyldimethylsilyl-4-demethoxydauno mycin. USE:Useful as an important synthetic intermediate for 13-methyl-13-dihydro-4- demethoxydaunorubicin having stro...

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Bibliographische Detailangaben
Hauptverfasser: OSAKI MASAKO, TERAJIMA ATSURO, SUZUKI MICHIYO, MATSUMOTO MITSUYO, YAMADA KAORU, KIMURA YOSHIICHI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Zusammenfassung:NEW MATERIAL:The 13-methyl-13-dihydro-4-demethoxydaunomycin derivative of formula I (R is H or trialkylsilyl). EXAMPLE:13-Methyl-13-dihydro-7-O-t-butyldimethylsilyl-4-demethoxydauno mycin. USE:Useful as an important synthetic intermediate for 13-methyl-13-dihydro-4- demethoxydaunorubicin having strong carcinostatic activity. PREPARATION:The compound of formula VI which is one of the compounds of formula I (R , R and R are alkyl; M is metallic atom or metal-containing atomic group) is produced, according to the reaction formula, by reacting a methylation agent to the compound of formula II having 7-OH group selectively protected with silyl group and desilylating the resultant compound of formula V.