3-OXAISOCARBACYCLINE COMPOUND AND PRODUCTION THEREOF

NEW MATERIAL:3-Oxoisocarbacycline compound of formula I [R is H, phenyl, 3-10C cycloalkyl, phenyl (1-2C) alkyl or one equivalent of cation; R and R are H, tri (1-7C) hydrocarbon-silyl or a group forming acetal bond together with O of hydroxyl group; R is H, 1-10C alkyl, vinyl or ethynyl; R is 1-10C...

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Hauptverfasser:	SAKAUCHI KIYOSHI, TANAKA TOSHIO, KUROZUMI SEIJI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:3-Oxoisocarbacycline compound of formula I [R is H, phenyl, 3-10C cycloalkyl, phenyl (1-2C) alkyl or one equivalent of cation; R and R are H, tri (1-7C) hydrocarbon-silyl or a group forming acetal bond together with O of hydroxyl group; R is H, 1-10C alkyl, vinyl or ethynyl; R is 1-10C alkyl, 2-10C alkenyl, 2-10C alkyl, 3-10C cycloalkyl, phenyl, phenoxy, etc.]. EXAMPLE:15-Deoxy-16-hydroxy-9(O)-methano-DELTA-3-oxaprost-a glandin I1. USE:A drug having prostaglandin-like activity and especially activities to protect cells and suppress the secretion of gastic acid. PREPARATION:The compound of formula I can be produced by reacting the compound of formula II [R and R are tri (1-7C) hydrocarbonsilyl, etc.] with the compound of formula III (X is Cl, etc.; R is H, etc.).