INHIBITOR OF BLOOD PLATELET AGGREGATION

INHIBITOR OF BLOOD PLATELET AGGREGATION

PURPOSE:A safe inhibitor of blood platelet aggregation having improved inhibitory action on blood platelet aggregation and extremely low toxicity, containing a specific compound extracted from seeds of Trichosanthes kirillowii MSXIMOWICZ var. japonicum KITAMURA, a cucurbitaceous plant as an active i...

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Hauptverfasser: NIITSU KAZUAKI, TAGUCHI HEIHACHIRO, IKETANI YUKINOBU
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator NIITSU KAZUAKI
TAGUCHI HEIHACHIRO
IKETANI YUKINOBU
description PURPOSE:A safe inhibitor of blood platelet aggregation having improved inhibitory action on blood platelet aggregation and extremely low toxicity, containing a specific compound extracted from seeds of Trichosanthes kirillowii MSXIMOWICZ var. japonicum KITAMURA, a cucurbitaceous plant as an active ingredient. CONSTITUTION:An inhibitor of blood platelet aggregation containing a compound shown by the formula I [R is H or group shown by the formula II (A is linoleoyl or oleoyl; B is tricosanoyl, linoleoyl or oleoyl)] as an active ingredient. 1,3-Ditricosanoyl-2-linoleoyl-glycerol (R = group shown by formula I and A is linoleoyl; B is tricosanoyl) among the compound shown by the formula I is obtained by extracting seeds of Trichosanthes kirillowii MAXIMOWICZ var. japonicum KITAMURA with water, methanol, etc., taking it partially by column chromatography, preparative liquid chromatography or high performance liquid chromatography and further hydrolyzed into tricosanoic acid where R=H. The inhibitor has excellent medicinal effect and safety.
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CONSTITUTION:An inhibitor of blood platelet aggregation containing a compound shown by the formula I [R is H or group shown by the formula II (A is linoleoyl or oleoyl; B is tricosanoyl, linoleoyl or oleoyl)] as an active ingredient. 1,3-Ditricosanoyl-2-linoleoyl-glycerol (R = group shown by formula I and A is linoleoyl; B is tricosanoyl) among the compound shown by the formula I is obtained by extracting seeds of Trichosanthes kirillowii MAXIMOWICZ var. japonicum KITAMURA with water, methanol, etc., taking it partially by column chromatography, preparative liquid chromatography or high performance liquid chromatography and further hydrolyzed into tricosanoic acid where R=H. 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The inhibitor has excellent medicinal effect and safety.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD39PPwdPIM8Q9S8HdTcPLx93dRCPBxDHH1cQ1RcHR3D3J1dwzx9PfjYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxXgHBZkaGBhYWhsaOxsSoAQDmUiQQ</recordid><startdate>19870520</startdate><enddate>19870520</enddate><creator>NIITSU KAZUAKI</creator><creator>TAGUCHI HEIHACHIRO</creator><creator>IKETANI YUKINOBU</creator><scope>EVB</scope></search><sort><creationdate>19870520</creationdate><title>INHIBITOR OF BLOOD PLATELET AGGREGATION</title><author>NIITSU KAZUAKI ; TAGUCHI HEIHACHIRO ; IKETANI YUKINOBU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS62108813A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NIITSU KAZUAKI</creatorcontrib><creatorcontrib>TAGUCHI HEIHACHIRO</creatorcontrib><creatorcontrib>IKETANI YUKINOBU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NIITSU KAZUAKI</au><au>TAGUCHI HEIHACHIRO</au><au>IKETANI YUKINOBU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITOR OF BLOOD PLATELET AGGREGATION</title><date>1987-05-20</date><risdate>1987</risdate><abstract>PURPOSE:A safe inhibitor of blood platelet aggregation having improved inhibitory action on blood platelet aggregation and extremely low toxicity, containing a specific compound extracted from seeds of Trichosanthes kirillowii MSXIMOWICZ var. japonicum KITAMURA, a cucurbitaceous plant as an active ingredient. CONSTITUTION:An inhibitor of blood platelet aggregation containing a compound shown by the formula I [R is H or group shown by the formula II (A is linoleoyl or oleoyl; B is tricosanoyl, linoleoyl or oleoyl)] as an active ingredient. 1,3-Ditricosanoyl-2-linoleoyl-glycerol (R = group shown by formula I and A is linoleoyl; B is tricosanoyl) among the compound shown by the formula I is obtained by extracting seeds of Trichosanthes kirillowii MAXIMOWICZ var. japonicum KITAMURA with water, methanol, etc., taking it partially by column chromatography, preparative liquid chromatography or high performance liquid chromatography and further hydrolyzed into tricosanoic acid where R=H. The inhibitor has excellent medicinal effect and safety.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title INHIBITOR OF BLOOD PLATELET AGGREGATION
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