PRODUCTION OF ARYLACETIC ACID ESTER

PURPOSE:In the production of the title compound, which is used as a starting material of medicines, by the reaction between a halogenated aryl compound, carbon monoxide and an alcohol, a rhodium compound is used to effect vapor- phase reaction, facilitate mixing of the starting materials and improve...

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Bibliographische Detailangaben
Hauptverfasser:	KOBAYASHI IWAO, SHINODA KIYONORI, TAMASHIMA KAZUO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE:In the production of the title compound, which is used as a starting material of medicines, by the reaction between a halogenated aryl compound, carbon monoxide and an alcohol, a rhodium compound is used to effect vapor- phase reaction, facilitate mixing of the starting materials and improve the reaction yield through simple operations. CONSTITUTION:In the presence of a rhodium compound as a catalyst, the vapor- phase reaction between carbon monoxide, a gaseous halogenated aryl compound and an alcohol is effected directly or in dilution with an inert gas at 100-300 deg.C to give the title compound. The rhodium compound as a catalyst is, e.g., RhCl3.3H2O; Rh(NO3)3 and preferably supported on a carrier. The carrier is preferably activated carbon and the amount of rhodium compound supported is 0.5-20wt% calculated as metallic rhodium. The amount of the alcohol and carbon monoxide used preferably is 2-100mol and 1-100mol per mole of the halogenated aryl compound, respectively.