NOVEL QUASSINOID COMPOUND AND THEIR PREPARATION

NEW MATERIAL:A compound of formula I (Glc is glucose residue; R is acetic acid residue, 3-methyl-2-butenoic acid residue, 3-methylbutanoic acid residue). EXAMPLE:Yadanzioside D of formula II. USE:Antitumor, antiviral agent. PREPARATION:ATANSHI [seeds of Brucea javanica (L.) Merr] are crushed, defatt...

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Bibliographische Detailangaben
Hauptverfasser:	TSUYUKI TAKAHIKO, TAKAHASHI TAKEMI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound of formula I (Glc is glucose residue; R is acetic acid residue, 3-methyl-2-butenoic acid residue, 3-methylbutanoic acid residue). EXAMPLE:Yadanzioside D of formula II. USE:Antitumor, antiviral agent. PREPARATION:ATANSHI [seeds of Brucea javanica (L.) Merr] are crushed, defatted with a hydrocarbon such as pentane and extracted with an alcohol such as methanol at room temperature or under heating. Then, the extract is partitioned with an organic solvent such as chloroform and water and brusatol is removed from the organic phase. The extract are concentrated to a dark- brown oil and the oil is purified by combination of a variety of chromatographies to give novel quassinoids, namely yadanziosides D, E and H.