MONOCLONAL ANTIBODY

NEW MATERIAL:An antibody 35-Lu65 of class IgM, having an antigenic determinant which is a sugar chain reacting and recognizing a glycoprotein antigen having >=1,000,000 molecular weight (measured by the gel filtration method), and having N- acetylgalactosamine at the terminal, and reactive with h...

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Hauptverfasser:	YAMADA TETSUJI, HIROHASHI AKIO, SHIMOZATO YUKIO, YANO HEIICHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	NEW MATERIAL:An antibody 35-Lu65 of class IgM, having an antigenic determinant which is a sugar chain reacting and recognizing a glycoprotein antigen having >=1,000,000 molecular weight (measured by the gel filtration method), and having N- acetylgalactosamine at the terminal, and reactive with human pulmonary noncellule cancer, only a part exhibiting epithelial differentiation in human pulmonary cellule cancer, human gastric cancer, pancreatic cancer, colonic cancer and mammary cancer, and further normal human bronchial epithelium, bronchial gland of the blood type A, sialaden, renal tubule, pancreatic exocrine gland, digestive tract epithelium, transitional eqithelium, squamous epithelial surface layer, erythrocytic membrane, vascular endothelium and intestinal epithelial metaplastic gastric mucous membrane. USE:A diagnostic agent for cancer. PREPARATION:A tumorous tissue is excised from a lymphonodus metastatic nest of a patient with human pulmonary giant cell carcinoma, and finely cut to prepare a cancer cell membrane fraction, which is used to immunize a mouse. The splenic cells of the mouse are subjected to cell fusion with mouse myelomatous cells, and the fused cells are cloned by the limiting dilution method and administered to an abdominal cavity of a mouse to give the aimed monoclonal antibody from the abdominal dropsy.