PRODUCTION OF 2-BROMO-ALPHA-ERGOCRYPTINE

The invention relates to a novel process for the preparation of 2-bromo- alpha -ergocryptine and its acid addition salt by brominating alpha -ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0...

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Bibliographische Detailangaben
Hauptverfasser: BEERA SUTEFUKOO, ERIKU BOKUSUCHIYU, YAANOSU GARAMUBOSU, FUERENTSU TORISHIYUCHIYURERU, GAABORU MEJIYUERI, RAIOSU KOBAACHIE, TEIBORU KEBE
Format: Patent
Sprache:eng
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Zusammenfassung:The invention relates to a novel process for the preparation of 2-bromo- alpha -ergocryptine and its acid addition salt by brominating alpha -ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0.02% of water and, if desired, converting the thus-obtained 2-bromo- alpha -ergocryptine to an acid addition salt in a known manner.