NOVEL CEPHALOSPORIN DERIVATIVE AND ITS PREPARATION

NOVEL CEPHALOSPORIN DERIVATIVE AND ITS PREPARATION

NEW MATERIAL:The compound of formula I {R is 1-5C alkyl, 3-6C cycloalkanomethyl (the above groups may be substituted with halogen), or group of formula II [m is 0-3; A is -COR (R is 1-5C alkyl, alkenyl, O, or -(CH2)pB (p is 0-3; B is amino, alkyl-substituted amino, OH, COOH, CN, etc.); n is 3-5}. EX...

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Hauptverfasser: TSURUOKA TAKASHI, NAKABAYASHI AKIRA, KATANO KIYOAKI, OGINO HIROKO, IWAMATSU KATSUYOSHI, YOSHIDA TAKASHI, KONDOU SHINICHI, INOUE SHIGEHARU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:NEW MATERIAL:The compound of formula I {R is 1-5C alkyl, 3-6C cycloalkanomethyl (the above groups may be substituted with halogen), or group of formula II [m is 0-3; A is -COR (R is 1-5C alkyl, alkenyl, O, or -(CH2)pB (p is 0-3; B is amino, alkyl-substituted amino, OH, COOH, CN, etc.); n is 3-5}. EXAMPLE:Syn-7-[2-( 2-aminothiazol-4-yl )2-methoxyiminoacetamido]-3-( 2,3-cyclopenteno-1-carboxymethylpyridinium-4-yl )thiomethyl-3-cephem-4-carboxylic acid sodium salt. USE:Antibacterial agent effective to Gram-negative and Gram-positive bacteria. PREPARATION:The objective compound can be prepared by reacting the compound of formula IV with the 2-(2aminothiazol-4-yl) 2-syn-substituted-oxyiminoacetatic acid of formula V (R is H or aminoprotecting group; R is same as R ), etc.