LOW-HEMOLYSIS VITAMIN E INJECTION SOLUTION

PURPOSE:The title injection solution that is obtained by adding a specific saccharide to an aqueous injection solution of vitamin E which has been solubilized with a nonionic surface active agent, thus showing extremely lower hemolysis than conventional solutions and causing no clouding with high stability for a long period of time. CONSTITUTION:A vitamin E which has been solubilized with a nonionic surface active agent such as hardened castor oil polyoxyethylene derivative is dissolved in water to prepare a aqueous injection solution of vitamin E and it is bombined with 1.0-20wt% of mono-, di-saccharide, sugar alcohol to give the objective vitamin E injection solution of reduced hemolysis. It was found that the addition of a saccharide can lower than hemolysis caused by the surface active agent. The hemolysis in this injection solution is almost same a in case where it is give orally, therefore it can be safely used in intramuscular and intravenous injections.