N-BENZOYL-N'-PYRIMIDINYLUREA AND ANTICANCER CONTAINING THE SAME

NEW MATERIAL:N-Benzoyl-N'-pyrimidinyloxyphenyl urea of formula I (X is H, halogen, nitro, CF3; Y is H, halogen, CF3; Z is H, halogen; when Z is halogen, at least one of Z and Y is CF3). EXAMPLE:N-( 2-Nitrobenzoyl )-N'-[ 3-trifluoromethyl-4- ( 5-iodo-2-pyrimizinyloxy)- phenyl]urea. USE:Anti...

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Hauptverfasser:	SUGI HIDEO, KOYANAGI TOORU, HAGA TAKAHIRO, OKADA HIROSHI, YAMADA SHIYUUITSU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:N-Benzoyl-N'-pyrimidinyloxyphenyl urea of formula I (X is H, halogen, nitro, CF3; Y is H, halogen, CF3; Z is H, halogen; when Z is halogen, at least one of Z and Y is CF3). EXAMPLE:N-( 2-Nitrobenzoyl )-N'-[ 3-trifluoromethyl-4- ( 5-iodo-2-pyrimizinyloxy)- phenyl]urea. USE:Anticancer agent. PREPARATION:For example, the reaction of a phenyl isocyanate of formula IIwith an aniline of formula III is conducted in a solvent such as benzene or toluene at about 0-120 deg.C to give the compound of formula I.