PHENACYL DERIVATIVE

NEW MATERIAL:A compound shown by the formula I (R1 and R2 are H, halogen, lower alkyl, hydroxy, or lower alkoxy) or its acid addition salt. EXAMPLE:2-[N-(2,6-Dichorophenyl)-N-phenacylamino]-2-imidazoline. USE:A preventive and remedy for cardiac incompetence or diseases of coronary artery, or arrhyth...

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Bibliographische Detailangaben
Hauptverfasser:	UEDA YOICHIRO, AWAYA AKIRA, SATO KAZUO, KAMIYA JOJI, KITANO TAKASHI, SHIRAI SHUZO, NAKANO TAKUO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound shown by the formula I (R1 and R2 are H, halogen, lower alkyl, hydroxy, or lower alkoxy) or its acid addition salt. EXAMPLE:2-[N-(2,6-Dichorophenyl)-N-phenacylamino]-2-imidazoline. USE:A preventive and remedy for cardiac incompetence or diseases of coronary artery, or arrhythmia of heart. A hypotensive. An anti-inflammatory drug. An analgesic. PREPARATION:A 2-(2,6-dichloroanilino)-2-imidazoline shown by the formula II is reacted with a substituted phenacyl derivative shown by the formula III (X is halogen, paratoluenesulfonyloxy, etc.) to give a compound shown by the formula I.