DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT
NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is (CH2)mOR [R is H, CH2CH(OH)CH2OCH2CH3, etc.; m is 1-4], CH(CH3)CH2OR , CH= CHCOOR (R is H or lower alkyl), (CH2)nCOOR (n is 1-3), etc.; R is 4-(lower alkyl)piperazino, 4-(lower alkyl)homopiperazino, or Y-(CH2)eNR R (Y is NH, etc.; R and...
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| creator | OSHIMA ETSUO OOMORI TAKEMORI ISHII HIDEMORI KUMAZAWA TOSHIAKI OBASE HIROYUKI SHUDO KATSUICHI |
| description | NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is (CH2)mOR [R is H, CH2CH(OH)CH2OCH2CH3, etc.; m is 1-4], CH(CH3)CH2OR , CH= CHCOOR (R is H or lower alkyl), (CH2)nCOOR (n is 1-3), etc.; R is 4-(lower alkyl)piperazino, 4-(lower alkyl)homopiperazino, or Y-(CH2)eNR R (Y is NH, etc.; R and R are lower alkyl; e is 2-5)} or its salt. EXAMPLE:11-(4-Methylhomopiperazino)-6,11-dihydrodibenzo[b, e] oxepine-2-acetic acid. USE:It has anti-allergic activity and is useful as a medicinal drug such as antiasthmatic, etc. PREPARATION:The compound of formula Ia can be prepared according to the reaction formula, by reacting the compound of formula II [R is (CH2)nCOOR (R is lower alkyl), etc.] with thionyl chloride, and reacting the reaction product with the compound of formula III. |
| format | Patent |
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EXAMPLE:11-(4-Methylhomopiperazino)-6,11-dihydrodibenzo[b, e] oxepine-2-acetic acid. USE:It has anti-allergic activity and is useful as a medicinal drug such as antiasthmatic, etc. PREPARATION:The compound of formula Ia can be prepared according to the reaction formula, by reacting the compound of formula II [R is (CH2)nCOOR (R is lower alkyl), etc.] with thionyl chloride, and reacting the reaction product with the compound of formula III.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860711&DB=EPODOC&CC=JP&NR=S61152670A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860711&DB=EPODOC&CC=JP&NR=S61152670A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OSHIMA ETSUO</creatorcontrib><creatorcontrib>OOMORI TAKEMORI</creatorcontrib><creatorcontrib>ISHII HIDEMORI</creatorcontrib><creatorcontrib>KUMAZAWA TOSHIAKI</creatorcontrib><creatorcontrib>OBASE HIROYUKI</creatorcontrib><creatorcontrib>SHUDO KATSUICHI</creatorcontrib><title>DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT</title><description>NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is (CH2)mOR [R is H, CH2CH(OH)CH2OCH2CH3, etc.; m is 1-4], CH(CH3)CH2OR , CH= CHCOOR (R is H or lower alkyl), (CH2)nCOOR (n is 1-3), etc.; R is 4-(lower alkyl)piperazino, 4-(lower alkyl)homopiperazino, or Y-(CH2)eNR R (Y is NH, etc.; R and R are lower alkyl; e is 2-5)} or its salt. EXAMPLE:11-(4-Methylhomopiperazino)-6,11-dihydrodibenzo[b, e] oxepine-2-acetic acid. USE:It has anti-allergic activity and is useful as a medicinal drug such as antiasthmatic, etc. PREPARATION:The compound of formula Ia can be prepared according to the reaction formula, by reacting the compound of formula II [R is (CH2)nCOOR (R is lower alkyl), etc.] with thionyl chloride, and reacting the reaction product with the compound of formula III.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1986</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB18XRy9Yvy13DScdX0j3AN8PRzVXBxDfIMcwzxDHNVcPRzAeIQT0cfH9cgd09nBUd3V78QHgbWtMSc4lReKM3NoOjmGuLsoZtakB-fWlyQmJyal1oS7xUQbGZoaGpkZm7gaEyMGgDaYCe3</recordid><startdate>19860711</startdate><enddate>19860711</enddate><creator>OSHIMA ETSUO</creator><creator>OOMORI TAKEMORI</creator><creator>ISHII HIDEMORI</creator><creator>KUMAZAWA TOSHIAKI</creator><creator>OBASE HIROYUKI</creator><creator>SHUDO KATSUICHI</creator><scope>EVB</scope></search><sort><creationdate>19860711</creationdate><title>DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT</title><author>OSHIMA ETSUO ; OOMORI TAKEMORI ; ISHII HIDEMORI ; KUMAZAWA TOSHIAKI ; OBASE HIROYUKI ; SHUDO KATSUICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS61152670A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1986</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OSHIMA ETSUO</creatorcontrib><creatorcontrib>OOMORI TAKEMORI</creatorcontrib><creatorcontrib>ISHII HIDEMORI</creatorcontrib><creatorcontrib>KUMAZAWA TOSHIAKI</creatorcontrib><creatorcontrib>OBASE HIROYUKI</creatorcontrib><creatorcontrib>SHUDO KATSUICHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OSHIMA ETSUO</au><au>OOMORI TAKEMORI</au><au>ISHII HIDEMORI</au><au>KUMAZAWA TOSHIAKI</au><au>OBASE HIROYUKI</au><au>SHUDO KATSUICHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT</title><date>1986-07-11</date><risdate>1986</risdate><abstract>NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is (CH2)mOR [R is H, CH2CH(OH)CH2OCH2CH3, etc.; m is 1-4], CH(CH3)CH2OR , CH= CHCOOR (R is H or lower alkyl), (CH2)nCOOR (n is 1-3), etc.; R is 4-(lower alkyl)piperazino, 4-(lower alkyl)homopiperazino, or Y-(CH2)eNR R (Y is NH, etc.; R and R are lower alkyl; e is 2-5)} or its salt. EXAMPLE:11-(4-Methylhomopiperazino)-6,11-dihydrodibenzo[b, e] oxepine-2-acetic acid. USE:It has anti-allergic activity and is useful as a medicinal drug such as antiasthmatic, etc. PREPARATION:The compound of formula Ia can be prepared according to the reaction formula, by reacting the compound of formula II [R is (CH2)nCOOR (R is lower alkyl), etc.] with thionyl chloride, and reacting the reaction product with the compound of formula III.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT |
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