DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT

NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is (CH2)mOR [R is H, CH2CH(OH)CH2OCH2CH3, etc.; m is 1-4], CH(CH3)CH2OR , CH= CHCOOR (R is H or lower alkyl), (CH2)nCOOR (n is 1-3), etc.; R is 4-(lower alkyl)piperazino, 4-(lower alkyl)homopiperazino, or Y-(CH2)eNR R (Y is NH, etc.; R and R are lower alkyl; e is 2-5)} or its salt. EXAMPLE:11-(4-Methylhomopiperazino)-6,11-dihydrodibenzo[b, e] oxepine-2-acetic acid. USE:It has anti-allergic activity and is useful as a medicinal drug such as antiasthmatic, etc. PREPARATION:The compound of formula Ia can be prepared according to the reaction formula, by reacting the compound of formula II [R is (CH2)nCOOR (R is lower alkyl), etc.] with thionyl chloride, and reacting the reaction product with the compound of formula III.