DIBENZO(B,E)OXEPINE DERIVATIVE AND ANTIALLERGIC AGENT

NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is H or methyl; one of R and R is COR [R is hydroxy, lower alkoxy, 1-(ethoxycarbonyloxy)ethoxy, or amino] or cyano and the other is H; R is 4-methylpiperazino or Y-(CH2)nNR R (Y is NH, O or S; n is 2-4; R and R are H or lower alkyl)} or its...

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Bibliographische Detailangaben
Hauptverfasser:	OSHIMA ETSUO, OOMORI TAKEMORI, ISHII HIDEMORI, KUMAZAWA TOSHIAKI, OBASE HIROYUKI, SHUDO KATSUICHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I {R is H or methyl; one of R and R is COR [R is hydroxy, lower alkoxy, 1-(ethoxycarbonyloxy)ethoxy, or amino] or cyano and the other is H; R is 4-methylpiperazino or Y-(CH2)nNR R (Y is NH, O or S; n is 2-4; R and R are H or lower alkyl)} or its salt. EXAMPLE:11-(4-Methylpiperazino)-6,11-dihydrodibenzo[b, e] oxepine-3-carboxylic acid methyl ester. USE:Useful as an anti-allergic agent. Administered preferably by oral administration or by injection. PREPARATION:The compound of formula Ia can be prepared according to the reaction formula, by reacting the compound of formula II [one of R and R is COR (R is lower alkoxy, etc.) and the other is H] with thionyl chloride in a solvent, and reacting the reaction product with the compound of formula III.