PRODUCTION OF (S)-GAMMA-HALO-BETA-HYDROXYBUTYRIC ACID ESTER

PURPOSE:To obtain an optically active (S)-gamma-halo-beta-hydroxybutyric acid ester which is an optically active compound exhibiting physiological activity, extremely economically, by the microbial asymmetric reduction of a gamma-halo-acetoacetic acid ester. CONSTITUTION:The (S)-gamma-halo-beta-hydr...

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Hauptverfasser:	WATANABE KIYOSHI, SHIMADA YOSHIO, YANAGIDA YOSHIBUMI, TAKAHASHI SATOMI, YAMADA YUKIO, UEDA YASUYOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain an optically active (S)-gamma-halo-beta-hydroxybutyric acid ester which is an optically active compound exhibiting physiological activity, extremely economically, by the microbial asymmetric reduction of a gamma-halo-acetoacetic acid ester. CONSTITUTION:The (S)-gamma-halo-beta-hydroxybutyric acid ester of formula II is prepared by treating a gamma-halo-acetoacetic acid ester of formula I (X is halogen; R is alkyl, aryl or their substituted group) with a microbial strain capable of effecting the (S)-stereospecific asymmetric reduction of the beta-carbonyl group (preferably at yeast selected from the group of Candida genus, Debaryomyces genus, Endomyces genus, Geotricum genus, Hansenula genus, Pichia genus, Saccharomyces genus, Torulopsis genus and Trichosporon genus).