OCTAHYDROINDOLO(2,3-A)QUINOLIDIN-1-YL- ALKANE CARBOXYLIC ACID AMIDE
The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),whereinR, and R2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C1-4 alkoxy group;R3 and R4 represent a hydrogen atom or a C1-4 alkyl group;R5...
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| creator | FUERENTSU SOOTEI TSUABA SAANTAI YUDEITO MATOUZU EREMEERU EZUERU RAASUROO SUPORUNIYU TSUABA KUTOHI MAARIA INTSUE JIYOORUJI HAYOOSU JIEUJIEANNA BAROGUHA |
| description | The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),whereinR, and R2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C1-4 alkoxy group;R3 and R4 represent a hydrogen atom or a C1-4 alkyl group;R5 and R6 represent a hydrogen atom, C1-8 alkyl group, C3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; orR5 and R6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; andG means a C1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds.Furthermore, the invention relates to a process for preparing these compounds and compositions.The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important. |
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The gastrocytoprotective effect is particularly important.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860613&DB=EPODOC&CC=JP&NR=S61126086A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860613&DB=EPODOC&CC=JP&NR=S61126086A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUERENTSU SOOTEI</creatorcontrib><creatorcontrib>TSUABA SAANTAI</creatorcontrib><creatorcontrib>YUDEITO MATOUZU</creatorcontrib><creatorcontrib>EREMEERU EZUERU</creatorcontrib><creatorcontrib>RAASUROO SUPORUNIYU</creatorcontrib><creatorcontrib>TSUABA KUTOHI</creatorcontrib><creatorcontrib>MAARIA INTSUE</creatorcontrib><creatorcontrib>JIYOORUJI HAYOOSU</creatorcontrib><creatorcontrib>JIEUJIEANNA BAROGUHA</creatorcontrib><title>OCTAHYDROINDOLO(2,3-A)QUINOLIDIN-1-YL- ALKANE CARBOXYLIC ACID AMIDE</title><description>The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),whereinR, and R2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C1-4 alkoxy group;R3 and R4 represent a hydrogen atom or a C1-4 alkyl group;R5 and R6 represent a hydrogen atom, C1-8 alkyl group, C3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; orR5 and R6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; andG means a C1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds.Furthermore, the invention relates to a process for preparing these compounds and compositions.The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. 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The gastrocytoprotective effect is particularly important.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | OCTAHYDROINDOLO(2,3-A)QUINOLIDIN-1-YL- ALKANE CARBOXYLIC ACID AMIDE |
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