OCTAHYDROINDOLO(2,3-A)QUINOLIDIN-1-YL- ALKANE CARBOXYLIC ACID AMIDE

The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),whereinR, and R2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C1-4 alkoxy group;R3 and R4 represent a hydrogen atom or a C1-4 alkyl group;R5 and R6 represent a hydrogen atom, C1-8 alkyl group, C3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; orR5 and R6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; andG means a C1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds.Furthermore, the invention relates to a process for preparing these compounds and compositions.The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.