7ALPHA-SUBSTITUTED 3-OXO-17ALPHA-PREGN-4- ENE-21,17-CARBOLACTONE, MANUFACTURE AND ANTIALDOSTERONIC PHARMACEUTICAL MEDICINE

7ALPHA-SUBSTITUTED 3-OXO-17ALPHA-PREGN-4- ENE-21,17-CARBOLACTONE, MANUFACTURE AND ANTIALDOSTERONIC PHARMACEUTICAL MEDICINE

7 alpha -Alkoxycarbonyl-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactones and their 21-carboxylic acid salts of the general formula I are described, in which R is an alkyl group with 1 to 4 carbon atoms is a CC single or CC double bond or the group and is a CC single bond or the group where at least o...

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Hauptverfasser: RUDORUFU BUIIHIERUTO, PEETAA ESUPERURINGU, KURAUSU NIKISHIYU, DEIITAA BITORAA, BUORUFUGANGU ROOZERUTO, HENRII RAURENTO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Zusammenfassung:7 alpha -Alkoxycarbonyl-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactones and their 21-carboxylic acid salts of the general formula I are described, in which R is an alkyl group with 1 to 4 carbon atoms is a CC single or CC double bond or the group and is a CC single bond or the group where at least one 1 alpha ,2 alpha - or 15 alpha ,16 alpha -methylene group must be present, and X is the group where M is an alkali metal. The compounds of the general formula I have a strong antialdosterone action and low antiandrogenic side effects.