2-AZABICYLO(2,2,2)OCTANE DERIVATIVE

2-AZABICYLO(2,2,2)OCTANE DERIVATIVE

2-Azabicyclo[2.2.2]octane derivatives of formula (I), …… wherein… A is hydrogen, (C1-4 alkoxy)carbonyl, phenyl (C1-4 alkoxy)carbonyl, C1-6 alkyl, aryl (C1-4 alkyl) or optionally substituted aryl (C2-5 alkanoyl),… R1 is hydrogen or C1-4 alkyl,… Z is hydrogen or halogen, and… either X and Y are each h...

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Bibliographische Detailangaben
Hauptverfasser: ERUMERU EZERU, CHIYABA SUZANTAI, TEIBORU ACHI, JIERUJI HAYOSU, JIERUJI FUEKETE, GABORU MEJIERI, HEDOBIGU BORUCHIKEI, RASURO SUPORUNII, TEIBORU KEBE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:2-Azabicyclo[2.2.2]octane derivatives of formula (I), …… wherein… A is hydrogen, (C1-4 alkoxy)carbonyl, phenyl (C1-4 alkoxy)carbonyl, C1-6 alkyl, aryl (C1-4 alkyl) or optionally substituted aryl (C2-5 alkanoyl),… R1 is hydrogen or C1-4 alkyl,… Z is hydrogen or halogen, and… either X and Y are each hydrogen or X and Y together represent a C-C bond and W is (C1-4 alkoxy)carbonyl, cyano, carboxamido or haloformyl… or X is halogen and W and Y together represent a -@-O-…… group;… and, where A is hydrogen, acid addition salts thereof, are disclosed which compounds possess interesting anticonvulsive, vasodilating, immunosuppressant and/or gastric acid secretion inhibiting properties. They are also of use as intermediates in the preparation of other active compounds. … Process for preparing them and pharmaceutical compositions containing them are also disclosed.