BENZOYLPROPIONIC ACID DERIVATIVE
NEW MATERIAL:A compound expressed by formula I (R represents H, lower alkyl or benzyl; R represents lower alkyl or phenyl; X represents H, halogen atom, lower alkyl, phenoxyl or halogenophenoxyl; Y represents H or lower alkyl). EXAMPLE:2-Acetylthiomethyl-3-benzoylpropionic acid. USE:Useful as a reme...
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| creator | SODA KAORU KAMEO KAZUYA MATSUNAGA TOORU TOMIZAWA KAZUYUKI SAITOU HIDEJI |
| description | NEW MATERIAL:A compound expressed by formula I (R represents H, lower alkyl or benzyl; R represents lower alkyl or phenyl; X represents H, halogen atom, lower alkyl, phenoxyl or halogenophenoxyl; Y represents H or lower alkyl). EXAMPLE:2-Acetylthiomethyl-3-benzoylpropionic acid. USE:Useful as a remedy for a disease caused by deficiency in an immunological function such as rheumarthritis, autoimmune disease, cancer, asthma, etc., having an excellent immunoregulating function with low side effects and low toxicity. PREPARATION:A carboxylic acid compound expressed by formula II is dissolved in an organic solvent such as methanol, added with 1-2 equivalents carbothiolic acid expressed by the formula R COSH, and reacted at -20-50 deg.C for 0.5-24hr in the presence of 0.01-0.1 equivalent basic catalyst to obtain the compound expressed by formula I. |
| format | Patent |
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EXAMPLE:2-Acetylthiomethyl-3-benzoylpropionic acid. USE:Useful as a remedy for a disease caused by deficiency in an immunological function such as rheumarthritis, autoimmune disease, cancer, asthma, etc., having an excellent immunoregulating function with low side effects and low toxicity. PREPARATION:A carboxylic acid compound expressed by formula II is dissolved in an organic solvent such as methanol, added with 1-2 equivalents carbothiolic acid expressed by the formula R COSH, and reacted at -20-50 deg.C for 0.5-24hr in the presence of 0.01-0.1 equivalent basic catalyst to obtain the compound expressed by formula I.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1985</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851220&DB=EPODOC&CC=JP&NR=S60258160A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851220&DB=EPODOC&CC=JP&NR=S60258160A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SODA KAORU</creatorcontrib><creatorcontrib>KAMEO KAZUYA</creatorcontrib><creatorcontrib>MATSUNAGA TOORU</creatorcontrib><creatorcontrib>TOMIZAWA KAZUYUKI</creatorcontrib><creatorcontrib>SAITOU HIDEJI</creatorcontrib><title>BENZOYLPROPIONIC ACID DERIVATIVE</title><description>NEW MATERIAL:A compound expressed by formula I (R represents H, lower alkyl or benzyl; R represents lower alkyl or phenyl; X represents H, halogen atom, lower alkyl, phenoxyl or halogenophenoxyl; Y represents H or lower alkyl). EXAMPLE:2-Acetylthiomethyl-3-benzoylpropionic acid. USE:Useful as a remedy for a disease caused by deficiency in an immunological function such as rheumarthritis, autoimmune disease, cancer, asthma, etc., having an excellent immunoregulating function with low side effects and low toxicity. PREPARATION:A carboxylic acid compound expressed by formula II is dissolved in an organic solvent such as methanol, added with 1-2 equivalents carbothiolic acid expressed by the formula R COSH, and reacted at -20-50 deg.C for 0.5-24hr in the presence of 0.01-0.1 equivalent basic catalyst to obtain the compound expressed by formula I.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1985</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBwcvWL8o_0CQjyD_D09_N0VnB09nRRcHEN8gxzDPEMc-VhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfFeAcFmBkamFoZmBo7GxKgBABoEInE</recordid><startdate>19851220</startdate><enddate>19851220</enddate><creator>SODA KAORU</creator><creator>KAMEO KAZUYA</creator><creator>MATSUNAGA TOORU</creator><creator>TOMIZAWA KAZUYUKI</creator><creator>SAITOU HIDEJI</creator><scope>EVB</scope></search><sort><creationdate>19851220</creationdate><title>BENZOYLPROPIONIC ACID DERIVATIVE</title><author>SODA KAORU ; KAMEO KAZUYA ; MATSUNAGA TOORU ; TOMIZAWA KAZUYUKI ; SAITOU HIDEJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS60258160A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1985</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SODA KAORU</creatorcontrib><creatorcontrib>KAMEO KAZUYA</creatorcontrib><creatorcontrib>MATSUNAGA TOORU</creatorcontrib><creatorcontrib>TOMIZAWA KAZUYUKI</creatorcontrib><creatorcontrib>SAITOU HIDEJI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SODA KAORU</au><au>KAMEO KAZUYA</au><au>MATSUNAGA TOORU</au><au>TOMIZAWA KAZUYUKI</au><au>SAITOU HIDEJI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BENZOYLPROPIONIC ACID DERIVATIVE</title><date>1985-12-20</date><risdate>1985</risdate><abstract>NEW MATERIAL:A compound expressed by formula I (R represents H, lower alkyl or benzyl; R represents lower alkyl or phenyl; X represents H, halogen atom, lower alkyl, phenoxyl or halogenophenoxyl; Y represents H or lower alkyl). EXAMPLE:2-Acetylthiomethyl-3-benzoylpropionic acid. USE:Useful as a remedy for a disease caused by deficiency in an immunological function such as rheumarthritis, autoimmune disease, cancer, asthma, etc., having an excellent immunoregulating function with low side effects and low toxicity. PREPARATION:A carboxylic acid compound expressed by formula II is dissolved in an organic solvent such as methanol, added with 1-2 equivalents carbothiolic acid expressed by the formula R COSH, and reacted at -20-50 deg.C for 0.5-24hr in the presence of 0.01-0.1 equivalent basic catalyst to obtain the compound expressed by formula I.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BENZOYLPROPIONIC ACID DERIVATIVE |
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