NOVEL CEPHALOSPORIN DERIVATIVE, AND PREPARATION THEREOF

NEW MATERIAL:A compound of formula I [R1 is H, 1-4C alkyl or formula II(m is an integer 0-3; R4 and R5 are H or lower alkyl; R6 is COOH or formula III); R2 and R3 are 1-5C alkyl or alkenyl; n is an integer 0-5] and a salt thereof. EXAMPLE:syn-7-[2-( 2-Aminothiazol-4-yl )-2-methoxyiminoacetamido]-3-(...

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Bibliographische Detailangaben
Hauptverfasser:	TSURUOKA TAKASHI, NAKABAYASHI AKIRA, OGINO HIROKO, KATANO KIYOAKI, IWAMATSU KATSUYOSHI, YOSHIDA TAKASHI, KONDOU SHINICHI, INOUE SHIGEHARU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound of formula I [R1 is H, 1-4C alkyl or formula II(m is an integer 0-3; R4 and R5 are H or lower alkyl; R6 is COOH or formula III); R2 and R3 are 1-5C alkyl or alkenyl; n is an integer 0-5] and a salt thereof. EXAMPLE:syn-7-[2-( 2-Aminothiazol-4-yl )-2-methoxyiminoacetamido]-3-( 5,6-cyclopentano-1-methylpyridinium-2-yl)thiomethyl-3-cephem-4-carboxy late. USE:An antimicrobial agent against Gram-negative and Gram-positive bacteria, etc. PREPARATION:A compound of formula IV, a salt or protected compound thereof is reacted with a 2-(2-aminothiazol-4-yl)2-syn-substituted oxyiminoacetic acid, etc. of formula V {R7 is H or a protecting group of amino group; R9 is H, 1-4C alkyl or formula VI [R ' is -COOR9(R9 is a protecting group of COOH)], etc.}.