SUBSTANCE FOR INHIBITING ANGIOTENSIN I CONVERTING ENZYME

PURPOSE:To obtain a substance 15B2 for inhibiting angiotensin I converting enzymes, by cultivating a microorganism belonging to actinomyces. CONSTITUTION:An actinomyces No.937ZE-1 strain (FERM-P No.7l32) separated newly from soil is capable of producing a substance 15B1 inhibiting angiotensin I conv...

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Hauptverfasser:	ABU MASAMI, KIDO YASUHITO, HAMAKADO TOSHINARI, MIYAGAWA EIJI, MOTOKI YOSHINOBU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF COMPOUNDS OF UNKNOWN CONSTITUTION CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a substance 15B2 for inhibiting angiotensin I converting enzymes, by cultivating a microorganism belonging to actinomyces. CONSTITUTION:An actinomyces No.937ZE-1 strain (FERM-P No.7l32) separated newly from soil is capable of producing a substance 15B1 inhibiting angiotensin I converting enzymes is newly found to produce further a substance 15B2 inhibiting angiotensin I converting enzymes. The physico-chemical properties of the substance are as follows; Constituent substances; Tyrosine and substances, positive to ninhydrin, having an area ratio of about twice that of the tyrosine measured by an amino acid analyzer, and contained in a hydrolyzate obtained by hydrolyzing the substance 15B2 at 110 deg.C for 20hr in 6N hydrochloric acid. Melting point; Showing no melting point up to 300 deg.C. Solubility, Readily soluble in aqueous solutions of alkalis, sparingly soluble in water and methanol and insoluble in ether, acetone and n-hexane. Color reactions; Positive to the iodine reaction and ferric chloride reaction and negative to ninhydrin and alpha-naphtholsulfuric acid reaction.