PREPARATION OF 1-(4-ISOPROPYLPHENYL)ETHYLAMINE

PURPOSE:To obtain the titled substance from inexpensive raw material in high yield easily, by carrying out simultaneously reduction of isopropenyl group of p-isopropenylacetophenone and reductive amination of carbonyl group in the presence of an Ni catalyst and ammonia. CONSTITUTION:p-Isopropenylace...

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Bibliographische Detailangaben
Hauptverfasser:	SAIGOU KAZUHIKO, KAI MARIKO, HASEGAWA MASAKI, NOHIRA HIROYUKI, YONEZAWA NOBUYUKI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain the titled substance from inexpensive raw material in high yield easily, by carrying out simultaneously reduction of isopropenyl group of p-isopropenylacetophenone and reductive amination of carbonyl group in the presence of an Ni catalyst and ammonia. CONSTITUTION:p-Isopropenylacetophenone (A) is used as a raw material, treated in the presence of an Ni catalyst and 3-7mol ammonia based on 1mol compound A in an alcohol solvent at 70-130 deg.C at 20-100kg/cm , so that reduction of isopropenyl group and reductive amination of carbonyl group are simultaneously carried out, to give the titled substance. Raney nickel catalyst, reductive nickel catalyst, or nickel catalyst obtained by decomposing thermally nickel formate, etc. are used as the catalyst. An amount of the catalyst used is preferably 2-20wt% calculated as Ni weight based on the compound A. USE:A purely synthetic basic optical resolution agent.