PURIFICATION OF RIBOFLAVIN MONOPHOSPHORIC ACID ESTER

PURPOSE:To recover the titled product in high yield and efficiency, by treating a solution of crude riboflavin monophosphoric acid ester with a column packed with a II-type strongly basic anion exchange resin and a column packed with crosslinked styrene polymer particles. CONSTITUTION:A 0.5-10% aque...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SUGIMOTO RIYUUICHI, KUSANO HIROSHI, SUGAWARA TOYOKAZU
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PURPOSE:To recover the titled product in high yield and efficiency, by treating a solution of crude riboflavin monophosphoric acid ester with a column packed with a II-type strongly basic anion exchange resin and a column packed with crosslinked styrene polymer particles. CONSTITUTION:A 0.5-10% aqueous solution of crude riboflavin monophosphoric acid ester (FMN) containing riboflavin and riboflavin polyphosphoric acid ester as impurities, is passed through a column packed with a II-type strongly basic anion exchange resin having a crosslinking degree of 3-10% and having benzylmethyl ethanol ammonium group as the functional group to recover riboflavin and FMN. Then, an aqueous solution of an inorganic salt is passed through the above column to elute and recover the adsorbed riboflavin polyphosphoric acid ester and FMN, and the eluate is passed through a column packed with crosslinked styrene polymer particles having a specific surface area of >=200m /g and a pore volume of >=0.2ml/g to separate the FMN.