OPTICAL RESOLUTION OF ALPHA-ISOPROPYL-P-CHLOROPHENYLACETIC ACID

PURPOSE:To obtain the (+)- or (-)-isomer of the titled substance, by reacting the substance with (+)- or (-)-alpha-phenyl-beta-(p-tolyl)ethylamine having high optical purity to crystallize (+)-(+) salt or (-)-(-) salt, and decomposing the obtained salt. CONSTITUTION:(A) alpha-isopropyl-p-chloropheny...

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Bibliographische Detailangaben
Hauptverfasser:	TAGUMA KENJI, MORINO HARUKI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain the (+)- or (-)-isomer of the titled substance, by reacting the substance with (+)- or (-)-alpha-phenyl-beta-(p-tolyl)ethylamine having high optical purity to crystallize (+)-(+) salt or (-)-(-) salt, and decomposing the obtained salt. CONSTITUTION:(A) alpha-isopropyl-p-chlorophenylacetic acid is made to react with (B) (+)- or (-)alpha-phenyl-beta-(p-tolyl)ethylamine having an optical purity of >=95% (preferably >=97%) at a molar ratio of 1:(0.6-0.8) to effect the selective crystallization of the (+)A-(+)B salt or (-)A-(-)B salt. The salt is separated and decomposed with an acid or alkali to obtain the objective (+)A to (-)A. When the system is temporally heated at 40-150 deg.C during or after the reaction, the optical purity of (+)A can be further improved.