PHTHALAZONE DERIVATIVE

NEW MATERIAL:The phthalazone derivative of formula (R and R' are 1-12C alkyl). EXAMPLE:4-Acetoxymethyl -2-acetyl -7-ethoxycarbonyl-6,8-dimethyl-1( 2H )-phthalazone. USE:Useful as a bioprecursor of phthalazinol which is a remedy effective to the subjective symptoms of the sequela of cerebrovascu...

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Bibliographische Detailangaben
Hauptverfasser:	WATANABE MARIKO, SHIRAI HIDEO, ISHIKAWA MASAYUKI, SAKAI YASUYUKI, SAITOU MORIHIRO, EBISAWA HISASHI, MORIGUCHI SOYAO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:The phthalazone derivative of formula (R and R' are 1-12C alkyl). EXAMPLE:4-Acetoxymethyl -2-acetyl -7-ethoxycarbonyl-6,8-dimethyl-1( 2H )-phthalazone. USE:Useful as a bioprecursor of phthalazinol which is a remedy effective to the subjective symptoms of the sequela of cerebrovascular disorder, the psychic symptoms, the central pain, etc. Although the compound has no physiological activity, it is converted to phthalazinol in the living body, and furthermore, it has higher solubility, absorbability to the body, and metabolic properties than phthalazinol. PROCESS:The compound of formula can be prepared, e.g. by using phthalazinol (known compound) as a starting compound, and reacting with a 1-12C carboxylic acid anhydride, halide, etc. preferably in a solvent such as pyridine.