NOVEL PEPTIDE

NEW MATERIAL:The peptide of formula I (R is pGlu-Lys-Ala-Lys-Ser, pGlu-Lys- Ala-Lys-Lys, or pGlu-Ala-Lys-Lys) or its slat. EXAMPLE:pGlu-Lys-Ala-Lys-Lys-Glu-Gly-Ser-Asn-OH. USE:Antibacterial agent and antiviral agent. PROCESS:The peptide of formula I can be prepared, e.g. by coupling the protected co...

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Bibliographische Detailangaben
Hauptverfasser:	HAGIWARA DAIJIROU, HASHIMOTO SHINJI, HENMI KEIJI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:The peptide of formula I (R is pGlu-Lys-Ala-Lys-Ser, pGlu-Lys- Ala-Lys-Lys, or pGlu-Ala-Lys-Lys) or its slat. EXAMPLE:pGlu-Lys-Ala-Lys-Lys-Glu-Gly-Ser-Asn-OH. USE:Antibacterial agent and antiviral agent. PROCESS:The peptide of formula I can be prepared, e.g. by coupling the protected constituent amino acids successively according to the conventional peptide synthesis method by a solid-phase process to obtain the compound of formula II (R is OH-protecting group; R is carboxy-protecting group; R is group of formula III, etc.; R is amino-protecting group), separating the protected peptide from a resin (e.g. benzhydrylamine resin), and removing the protecting groups. The coupling can be carried out in the presence of a condensation agent such as DCC in a solvent such as methylene chloride.