PREPARATION OF AZASERINE BY FERMENTATION

PREPARATION OF AZASERINE BY FERMENTATION

PURPOSE:To prepare azaserine useful as an antibacterial agent and antitumor agent, by culturing a microbial strain belonging to Microtetraspora genus. CONSTITUTION:Microorganism belonging to Microtetraspora genus and capable of producing azaserine, e.g. Microtetraspora glauca ATCC23057, is inoculate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TOMITA FUSAO, TAMAOKI TATSUYA, ODA SHIYOUJI, KAWAMOTO ISAO
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:PURPOSE:To prepare azaserine useful as an antibacterial agent and antitumor agent, by culturing a microbial strain belonging to Microtetraspora genus. CONSTITUTION:Microorganism belonging to Microtetraspora genus and capable of producing azaserine, e.g. Microtetraspora glauca ATCC23057, is inoculated in a nutrient medium, and cultured at 25-40 deg.C, preferably 28-38 deg.C, at 4-10pH, preferably 6-8pH, for about 1-7 days in a liquid medium, and the objective azaserine is separated from the culture liquid.