AMINO ACID DERIVATIVE AND HYPOTENSOR CONTAINING THE SAME

NEW MATERIAL:The amino acid derivative of formula I (R1 and R2 are OH, alkyloxy, aryloxy, aralkyloxy, alkyl, or arylaralkyl; R3, R5, R8 and R11 are H or alkyl; R4, R6, R7, R9 and R10 are H, alkyl, aryl or aralkyl; R12 is OH, alkyloxy, aryloxy, aralkyloxy, amino, mono- or di-alkyl, -aryl or -aralkyla...

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Hauptverfasser:	SAKAKIBARA SHIYUNPEI, YUMIKARI KOUZOU, HASHIMOTO SHIGEFUMI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:The amino acid derivative of formula I (R1 and R2 are OH, alkyloxy, aryloxy, aralkyloxy, alkyl, or arylaralkyl; R3, R5, R8 and R11 are H or alkyl; R4, R6, R7, R9 and R10 are H, alkyl, aryl or aralkyl; R12 is OH, alkyloxy, aryloxy, aralkyloxy, amino, mono- or di-alkyl, -aryl or -aralkylamino; R6, R7, R9 and R10 may together form an alkylene bridge). EXAMPLE:Dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline L-arginine salt. USE:Hypotensor. PROCESS:The compound of formula I can be prepared e.g. by reacting the tripeptide derivative of formula II with the phosphoridate of formula III (e.g. phosphochloridate diester) in the presence of a base such as triethylamine to convert the N-terminal to phosphorus derivative, and if ncessary, eliminating the protecting group.