ANTIBIOTIC PA-41746-A2 AND ITS PREPARATION

NEW MATERIAL:Antibiotic PA-41746-A2 and its salt. USE:Having antibacterial effect on Gram-positive and Gram-negative bacteria, improved beta-lactamase inhibitory action, useful as a drug as an antibacterial agent, an animal drug, or a disinfectant. Being administred to mem and animals orally or pare...

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Bibliographische Detailangaben
Hauptverfasser:	KONDOU EIJI, TSUJI NAOKI, MATSUMOTO KOUICHI, TANAKA KENTAROU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:Antibiotic PA-41746-A2 and its salt. USE:Having antibacterial effect on Gram-positive and Gram-negative bacteria, improved beta-lactamase inhibitory action, useful as a drug as an antibacterial agent, an animal drug, or a disinfectant. Being administred to mem and animals orally or parenterally. Usable as a tablet, capsule, or powder as oral administration, and injection, paint, suppository, etc. as parenteral administration. A dose is generally about 1/10 - about several times that of cephalothin. Also usable as a raw material for pluracidomycin A. PREPARATION:A bacterium belonging to the genus Streptomyces, capable of producing PA-41746-A2, is cultivated in a medium, and the titled compound is obtained from the prepared culture. The medium contains a carbon source, nitrogen source, inorganic salt, etc. as a rule, and the cultivation is carried out by a process commonly used in preparation of antibiotic. Preferably the pH of the medium is 5.5-8.5 and the culture temperature is about 20-40 deg.C.