CYCLIC IMIDE DERIVATIVE AND ITS ACID ADDITION SALT

NEW MATERIAL:The compound of formula I (A is group of formula II or III; n is 3 or 4; R is 2-pyridyl or 2-pyrimidinyl) and its acid addition salt. EXAMPLE:N-{4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl}phthalimide hydrochloride. USE:An antianxiety agent having low side effects of central inhibition. PR...

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Hauptverfasser:	ANTOKU FUJIO, ISHIZUMI KIKUO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:The compound of formula I (A is group of formula II or III; n is 3 or 4; R is 2-pyridyl or 2-pyrimidinyl) and its acid addition salt. EXAMPLE:N-{4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl}phthalimide hydrochloride. USE:An antianxiety agent having low side effects of central inhibition. PREPARATION:The objective compound can be prepared by reacting the acid anhydride of formula IV (e.g. phthalic anhydride) with the amine derivative of formula V [e.g. 1-(4-aminobutyl)-4-(2-pyrimidinyl)-piperazine] preferably in an inert organic solvent such as pyridine.