BIOCHEMICAL PREPARATION OF OPTICALLY ACTIVE CARNITINE

PURPOSE:To prepare the titled compound useful as a drug effective to promote the digestive function, economically in an industrial scale, by treating apocarnitine which is a synthetic intermediate for the preparation of carnitine by chemical reaction, with an enzyme produced by microorganisms. CONST...

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Bibliographische Detailangaben
Hauptverfasser:	NAKAMURA USAO, UENO ETSUKO, TAKAO MAKOTO, KAWAGUCHI YOSHITAROU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To prepare the titled compound useful as a drug effective to promote the digestive function, economically in an industrial scale, by treating apocarnitine which is a synthetic intermediate for the preparation of carnitine by chemical reaction, with an enzyme produced by microorganisms. CONSTITUTION:An optically active carnitine is prepared by treating apocarnitine which is a synthetic intermediate for the preparation of carnitine by chemical reaction, with an enzyme produced by microorganisms. For example, Enterobacter sp. Y-239-b strain (FERM-P No.6976) belonging to Enterobacter genus is cultured in a medium added with apocarnitine sulfate, the culture liquid is centrifuged, the supernatant liquid is treated with a strongly acidic cation exchange resin and eluted with ammonia water, the eluate is concentrated in vacuum, and L-carnitine fraction is separated by high-performance liquid chromatography. Oily L-carnitine can be obtained from the above fraction.