ISOXAZOLE DERIVATIVE AND MANUFACTURE

ISOXAZOLE DERIVATIVE AND MANUFACTURE

The invention relates to new isoxazole derivatives of the general formula wherein X and Y which are the same or different, stand for a nitrile group, an optionally activated carboxylic group, a -CO2Z or -CONRR' group wherein Z represents a C1-6 alkyl group, R and R' represent a hydrogen at...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JIYURA HORUNIYAAKU, YOOJIEFU NIITORAI, KAARORI REMUPERUTO, KAARORI ZAUERU, GIYURA SHIMIGU, GAABORU DORESHIYUCHIYARU, YOOJIEFU FUETSUTERU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to new isoxazole derivatives of the general formula wherein X and Y which are the same or different, stand for a nitrile group, an optionally activated carboxylic group, a -CO2Z or -CONRR' group wherein Z represents a C1-6 alkyl group, R and R' represent a hydrogen atom, a phenyl or benzyl group or R and R' together with the nitrogen atom may form a heterocyclic ring, or X and Y together stand for an anhydride group of the formula By catalytic hydrogenation, the compounds of the formula (I) can be transformed to intermediates for the preparation of thienamycin, a known broad-spectrum antibiotic.