NOVEL PEPTIDE HAVING ANALGESIC ACTION AND ITS PREPARATION

NEW MATERIAL:A peptide shown by the formula (amino acid residue other than D-amino acid shows L-amino acid residue). USE:An analgesic. Since this peptide is linked to a receptor which is different from a mureceptor to which morphine is bonded and it shows analgesic action, it has no indulgence. PREP...

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Bibliographische Detailangaben
Hauptverfasser:	ARAKAWA YOSHIHIRO, IKEDA MASUHIRO, KANEKO TAKETOSHI, TACHIBANA SHINROU, YAMATSU KIYOMI, NAKAZAWA TAKAHIRO, OOYA SHIZUKO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A peptide shown by the formula (amino acid residue other than D-amino acid shows L-amino acid residue). USE:An analgesic. Since this peptide is linked to a receptor which is different from a mureceptor to which morphine is bonded and it shows analgesic action, it has no indulgence. PREPARATION:The titled peptide can be synthesized by solid-phase or liquid- phase method. When it is synthesized by solid-phase method, Gln having a protected N end is linked to a styrenic resin carrier by amide bond, the protecting group is removed, the resultant compound is condensed with Asn whose N end is previously protected with BOC to form a peptide bond. The amino acid whose N end and functional group at the side chain protected optionally in this way is condensed in the order of amino acid arrangement shown by the formula, to give a protected peptide shown by the formula, which is treated with hydrogen fluoride so that the protecting group and the resin are removed from it, to give the peptide shown by the formula.