MANUFACTURE OF 3-TRIFLUOROMETHYL- AND 2,5-DIMETHYL-4' -HYDROXY-ALPHA-ETHYL-BENZHYDROLS AND PHARMACEUTICAL COMPOSITION

The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics...

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Bibliographische Detailangaben
Hauptverfasser:	YOSEFU TOURUREI, EBA PAROSHI, RASURO BEREZETSUKII, EDEITO TOSU, JIYORUJII FUEKETE, RASURO SUPORUNII, SANDORU GURUGU, IMURE KUREBOBITSUCHI, PARU BITAI, ISUTOBAN HAJIYU
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.