SUBSTITUTED 5H-PYRIMIDO(5,4-B)INDOLE, MANUFACTURE AND PSYCHOTIC MEDICINE

Substituted 5H-pyrimido[5,4-b]indoles of Formula I (I) wherein R2 is halogen; the oxadiazolyl group wherein R'' is lower alkyl with up to 3 carbon atoms; C1-5-alkyl, cycloalkyl, aralkyl, or aryl; ORI, SOnRI with n being 0, 1, or 2, or wherein RI is hydrogen, C1-5-alkyl, cycloalkyl, aralkyl...

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Bibliographische Detailangaben
Hauptverfasser:	ANDOREASU FUUTO, HERUBERUTO HANSU SHIYUNAIDAA, DEIITAA RAATSU, BUORUFUGANGU KEERU, RARUFU SHIYUMIIHIEN, DEIITAA ZAIDERUMAN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Substituted 5H-pyrimido[5,4-b]indoles of Formula I (I) wherein R2 is halogen; the oxadiazolyl group wherein R'' is lower alkyl with up to 3 carbon atoms; C1-5-alkyl, cycloalkyl, aralkyl, or aryl; ORI, SOnRI with n being 0, 1, or 2, or wherein RI is hydrogen, C1-5-alkyl, cycloalkyl, aralkyl, or aryl; wherein RII and RIII are hydrogen, C1-5-alkyl, C3-5-alkenyl, cycloalkyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; and RA is hydrogen; the oxadiazolyl group wherein R'' is lower alkyl with up to 3 carbon atoms; halogen, nitro, ORI, SOnRI with n being 0, 1, or 2, wherein RI is hydrogen, C1-5-alkyl, cycloalkyl, aralkyl, or aryl; wherein RII and RIII are hydrogen, C1-5-alkyl, cycloalkyl, C3-5-alkenyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; or PO(OR)2 wherein R is C1-5-alkyl, exhibit strong affinity for binding to benzodiazepine receptors. The novel compounds are suitable for use in psychopharmaceutical preparations.