PERTUSSIS VACCINE CONTAINING B-OLIGOMER AND ITS PREPARATION
PURPOSE:To provide the titled vaccine having high activity and stability, by using a specific B-oligomer as an active component. CONSTITUTION:A pertussis vaccine is prepared by using the B-oligomer (molecular weight, 75,000+ or -5,000 by SDS-gel electrophoresis; protein content, >=98wt% by Lowry...
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| creator | ASE KATSUHIKO TAKAHASHI ISAMU TAMURA MAKOTO ITOU KIYOSHI YAJIMA MOTOYUKI TOMIOKA CHIKANORI SATOU SOUICHIROU |
| description | PURPOSE:To provide the titled vaccine having high activity and stability, by using a specific B-oligomer as an active component. CONSTITUTION:A pertussis vaccine is prepared by using the B-oligomer (molecular weight, 75,000+ or -5,000 by SDS-gel electrophoresis; protein content, >=98wt% by Lowry process; amino acid composition and composition ratios (muM/100muM) of the protein component, as shown in the table I ; basic protein) as an active component. The B-oligomer can be prepared by (1) culturing microorganisms belonging to Bordetella genus (e.g. Bordetella pertussis phase I ), (2) treating the supernatant liquid of the cultured liquid with hydroxyapatite to obtain crude fraction containing insulin-secretion promoting factor, (3) adding urea to the crude fraction to an ultimate urea concentration of 3-6M, (4) incubating the mixture, (5) treating with haptoglobin sepharose, and (6) purifying the product. |
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CONSTITUTION:A pertussis vaccine is prepared by using the B-oligomer (molecular weight, 75,000+ or -5,000 by SDS-gel electrophoresis; protein content, >=98wt% by Lowry process; amino acid composition and composition ratios (muM/100muM) of the protein component, as shown in the table I ; basic protein) as an active component. The B-oligomer can be prepared by (1) culturing microorganisms belonging to Bordetella genus (e.g. Bordetella pertussis phase I ), (2) treating the supernatant liquid of the cultured liquid with hydroxyapatite to obtain crude fraction containing insulin-secretion promoting factor, (3) adding urea to the crude fraction to an ultimate urea concentration of 3-6M, (4) incubating the mixture, (5) treating with haptoglobin sepharose, and (6) purifying the product.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840626&DB=EPODOC&CC=JP&NR=S59110626A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840626&DB=EPODOC&CC=JP&NR=S59110626A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ASE KATSUHIKO</creatorcontrib><creatorcontrib>TAKAHASHI ISAMU</creatorcontrib><creatorcontrib>TAMURA MAKOTO</creatorcontrib><creatorcontrib>ITOU KIYOSHI</creatorcontrib><creatorcontrib>YAJIMA MOTOYUKI</creatorcontrib><creatorcontrib>TOMIOKA CHIKANORI</creatorcontrib><creatorcontrib>SATOU SOUICHIROU</creatorcontrib><title>PERTUSSIS VACCINE CONTAINING B-OLIGOMER AND ITS PREPARATION</title><description>PURPOSE:To provide the titled vaccine having high activity and stability, by using a specific B-oligomer as an active component. 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The B-oligomer can be prepared by (1) culturing microorganisms belonging to Bordetella genus (e.g. Bordetella pertussis phase I ), (2) treating the supernatant liquid of the cultured liquid with hydroxyapatite to obtain crude fraction containing insulin-secretion promoting factor, (3) adding urea to the crude fraction to an ultimate urea concentration of 3-6M, (4) incubating the mixture, (5) treating with haptoglobin sepharose, and (6) purifying the product.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1984</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAOcA0KCQ0O9gxWCHN0dvb0c1Vw9vcLcfT08_RzV3DS9ffxdPf3dQ1ScPRzUfAMCVYICHINcAxyDPH09-NhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfFeAcGmloaGBmZGZo7GxKgBAPqXKcA</recordid><startdate>19840626</startdate><enddate>19840626</enddate><creator>ASE KATSUHIKO</creator><creator>TAKAHASHI ISAMU</creator><creator>TAMURA MAKOTO</creator><creator>ITOU KIYOSHI</creator><creator>YAJIMA MOTOYUKI</creator><creator>TOMIOKA CHIKANORI</creator><creator>SATOU SOUICHIROU</creator><scope>EVB</scope></search><sort><creationdate>19840626</creationdate><title>PERTUSSIS VACCINE CONTAINING B-OLIGOMER AND ITS PREPARATION</title><author>ASE KATSUHIKO ; TAKAHASHI ISAMU ; TAMURA MAKOTO ; ITOU KIYOSHI ; YAJIMA MOTOYUKI ; TOMIOKA CHIKANORI ; SATOU SOUICHIROU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS59110626A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1984</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ASE KATSUHIKO</creatorcontrib><creatorcontrib>TAKAHASHI ISAMU</creatorcontrib><creatorcontrib>TAMURA MAKOTO</creatorcontrib><creatorcontrib>ITOU KIYOSHI</creatorcontrib><creatorcontrib>YAJIMA MOTOYUKI</creatorcontrib><creatorcontrib>TOMIOKA CHIKANORI</creatorcontrib><creatorcontrib>SATOU SOUICHIROU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ASE KATSUHIKO</au><au>TAKAHASHI ISAMU</au><au>TAMURA MAKOTO</au><au>ITOU KIYOSHI</au><au>YAJIMA MOTOYUKI</au><au>TOMIOKA CHIKANORI</au><au>SATOU SOUICHIROU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PERTUSSIS VACCINE CONTAINING B-OLIGOMER AND ITS PREPARATION</title><date>1984-06-26</date><risdate>1984</risdate><abstract>PURPOSE:To provide the titled vaccine having high activity and stability, by using a specific B-oligomer as an active component. CONSTITUTION:A pertussis vaccine is prepared by using the B-oligomer (molecular weight, 75,000+ or -5,000 by SDS-gel electrophoresis; protein content, >=98wt% by Lowry process; amino acid composition and composition ratios (muM/100muM) of the protein component, as shown in the table I ; basic protein) as an active component. The B-oligomer can be prepared by (1) culturing microorganisms belonging to Bordetella genus (e.g. Bordetella pertussis phase I ), (2) treating the supernatant liquid of the cultured liquid with hydroxyapatite to obtain crude fraction containing insulin-secretion promoting factor, (3) adding urea to the crude fraction to an ultimate urea concentration of 3-6M, (4) incubating the mixture, (5) treating with haptoglobin sepharose, and (6) purifying the product.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | PERTUSSIS VACCINE CONTAINING B-OLIGOMER AND ITS PREPARATION |
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