PHENYLPROPANOL AMINE, MANUFACTURE AND USE

1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE) A phenylpropanolamine of the formula I see diagramm : EP0109623,P9,F3 where R**1 is hydrogen or halogen, R**2 is hydrogen, or a saturated or unsaturated hydrocarbon radical of up to 15 carbon atoms, R**3 is hydrogen, a satur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HANSU PEETAA HOFUMAN, MARUCHIN TORAUTO, HANSU IERUKU TORAIBAA, HORUSUTO KURAISUKOTSUTO, HANSUUYURUGEN TETSUSHIENDORUFU
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE) A phenylpropanolamine of the formula I see diagramm : EP0109623,P9,F3 where R**1 is hydrogen or halogen, R**2 is hydrogen, or a saturated or unsaturated hydrocarbon radical of up to 15 carbon atoms, R**3 is hydrogen, a saturated or unsaturated hydrocarbon radical of up to 3 carbon atoms, C1 -C4 -acyl, benzoyl, C2 -C4 -carbalkoxy or a carboxamido group -CO-NHR**6 , where R**6 is C1 -C4 -alkyl, R**4 is hydrogen or halogen, R**5 is dimethylamino, piperidino or pyrrolidono, and X is oxygen or sulfur, and its salts with physiologically tolerated acids. 1. Claims (for the Contracting State AT) A process for the preparation of a phenylpropanolamine of the formula I see diagramm : EP0109623,P10,F2 where R**1 is hydrogen or halogen, R**2 is hydrogen, or a saturated or unsaturated hydrocarbon radical of up to 15 carbon atoms, R**3 is hydrogen, a saturated or unsaturated hydrocarbon radical of up to 3 carbon atoms, C1 -C4 -acyl, benzoyl, C2 -C4 -carbalkoxy or a carboxamido group -CO-NHR**6 , where R**6 is C1 -C4 -alkyl, R**4 is hydrogen or halogen, R**5 is dimethylamino, piperidino or pyrrolidino, and X is oxygen or sulfur, and its salts with physiologically tolerated acids, wherein a compound of the formula II see diagramm : EP0109623,P10,F3 where R**1 , R**4 , R**5 and X have the above meanings, (a) is reduced, or (b) is reacted with an appropriately substituted organometallic compound, and, if desired, the compound thus obtained is etherified or esterified and/or converted into its salts with physiologically tolerated acids.