MICROBIAL CONVERSION OF ANTHRACYCLINE ANTIBIOTIC SUBSTANCE

PURPOSE:To convert the 9-position acetyl group of an anthracycline antibiotic substance to 1-hydroxyethyl group, effectively, in high yield, by reducing the group with a specific yeast. CONSTITUTION:An anthracycline antibiotic substance having an acetyl group at the 9-position, e.g. FA-1180-A (rubeo...

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Hauptverfasser:	SUGI HIDEO, MIZUKOSHI SADANORI, YAMADA SHIYUUITSU, MORI HIROYUKI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To convert the 9-position acetyl group of an anthracycline antibiotic substance to 1-hydroxyethyl group, effectively, in high yield, by reducing the group with a specific yeast. CONSTITUTION:An anthracycline antibiotic substance having an acetyl group at the 9-position, e.g. FA-1180-A (rubeomycin A), daunomycin, carminomycin, etc., or its acid addition salt, is reduced with a yeast belonging to Rhodotorula or Rhodosporidium genus. The acetyl group is converted to 1-hydroxyethyl group, and FA-1180-B (rubeomycin B), dihydrodaunomycin, dihydrocarminomycin, etc. can be prepared in high efficiency and yield, by this process.