4-HYDROXY-2-ORGANOTHIO-2-CYCLOPENTENONES AND THEIR PREPARATION

4-HYDROXY-2-ORGANOTHIO-2-CYCLOPENTENONES AND THEIR PREPARATION

NEW MATERIAL:A compound of formulaI[R , R are F, methyl, H; R is H, tri(1-6C)hydrocarbon-silyl group or group forming acetal likanges with the O atom in hydroxyl; G is -CH2OR (R is H, 2-7C acyl), -COOR (R is H, 1- 10C alkyl); where, when R is H, 1-10C alkyl, R , R are not H at a time]. EXAMPLE:4(RS)...

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Bibliographische Detailangaben
Hauptverfasser: SUGIURA SATOSHI, HASATO ATSUO, OKAMURA NORIAKI, TANAKA TOSHIO, SAKAUCHI KIYOSHI, YUU TAKESHI, KUROZUMI SEIJI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:NEW MATERIAL:A compound of formulaI[R , R are F, methyl, H; R is H, tri(1-6C)hydrocarbon-silyl group or group forming acetal likanges with the O atom in hydroxyl; G is -CH2OR (R is H, 2-7C acyl), -COOR (R is H, 1- 10C alkyl); where, when R is H, 1-10C alkyl, R , R are not H at a time]. EXAMPLE:4(RS)-t-Butyldimethylsilyloxy-2-(6-hydroxyhexylthio)-2-cyclope ntenone. USE:Synthetic intermediate of 7-thiaprostaglandins with an activity of inhibiting blood platelet coagulation. PREPARATION:The reaction between 2,3-epoxycyclopentanone of formula II and a mercaptan of formula III in the presence of a basic compound in an inert solvent gives the compound of formulaI.