13-HYDROXYMYCINAMICIN DERIVATIVE

NEW MATERIAL:A compound shown by the formulaI(A is a group shown by the formula II when R is H, a group shown by the formula III when R is OH, and a group shown by the formula IV when R is a group constituting 11,14- epoxy group; Q is a group constituting 11,14-epoxy). EXAMPLE:12,13-Deepoxy-13-hydro...

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Bibliographische Detailangaben
Hauptverfasser:	SAKAKIBARA HIDEO, SATOI SHIYUUZOU, MUTOU NAOKI, OONO MASARU, KINOSHITA KENJI, SHIBUYA YUUZOU, HAYASHI MITSUO, TAKADA MASAKI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound shown by the formulaI(A is a group shown by the formula II when R is H, a group shown by the formula III when R is OH, and a group shown by the formula IV when R is a group constituting 11,14- epoxy group; Q is a group constituting 11,14-epoxy). EXAMPLE:12,13-Deepoxy-13-hydroxymycinamicinI. USE:An oral or injection remedy for infectious deseases caused by Gram-positive bacteria or mycoplasm or an animal growth promotor. PROCESS:(A) Mycinamicin(MMN)Ior MMN II is reacted with an electron donor metal (e.g., zinc powder, etc.) and an ammonium salt (e.g., NH4Cl, etc.) in a hydrous polar solvent (e.g., water/tetrahydrofuran, etc.) or (B) a culture of a bacterium (e.g., Streptomyces variabilis TYJ-689, etc.) capable of converting MMNIor MMN II to the desired substance, its mold, or treated materials thereof are reacted with MMNIor MMN II in an aqueous medium in the absence of O2, to give a compound shown by the formulaI.