JPS5843388B

Procedure for the preparation of N-substituted 1-amino-3-phenoxy-propanoles- (2) of the general formula I **(See formula)** where R1 and R2 signify hydrogen atoms or together a valence line, a sulfur atom or an ethylene group; B means a straight or branched lower alcohol chain with 2 to 5 carbon atoms, which may optionally be substituted with a hydroxyl group; R3 means hydrogen or a lower alcohol group with 1 to 3 carbon atoms, and their salts, characterized in that amines of the general formula II are reacted **(See formula)** where R1, R2, R3 and B have the meanings mentioned above, with 1,2-epoxy-3-phenoxy-propane or its reactive derivatives; or b) compounds of the general formula III are reacted **(See formula)** where R1, R2 and B have the meanings mentioned above and where X represents a reactive group, and in case the compounds of formula I must be substituted in the alcoholic chain B with a hydroxyl group BX can also mean an epoxyalcoyl group, with amines of general formula IV **(See formula)** in which R3 has the meanings mentioned above, after which the compounds obtained are eventually transformed into their physiologically safe salts. (Machine-translation by Google Translate, not legally binding)