ALPHA-CYCLIC AMINOPHENYLACETIC ESTERS, THEIR ACID ADDITION SALTS AND QUATERNARY AMMONIUM SALTS

NEW MATERIAL:A compound shown by the formula I (R1 is H, halogen, OH, lower alkyl, CF3, or lower alkoxy; R2 is lower alkyl; Am is 5-9-membered cyclic amino group which may be replaced with lower alkyl; m and n are 1, 2, or 3, and m+n is 3, 4, or 5; with the proviso that a case where Am is piperidino...

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Hauptverfasser:	KADOKAWA TOSHIAKI, NISHIMURA ATSUKI, KAWASHIMA KATSUYOSHI, NARUTO SHIYUNSUKE, MIZUTA YASUYUKI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	KADOKAWA TOSHIAKI NISHIMURA ATSUKI KAWASHIMA KATSUYOSHI NARUTO SHIYUNSUKE MIZUTA YASUYUKI
description	NEW MATERIAL:A compound shown by the formula I (R1 is H, halogen, OH, lower alkyl, CF3, or lower alkoxy; R2 is lower alkyl; Am is 5-9-membered cyclic amino group which may be replaced with lower alkyl; m and n are 1, 2, or 3, and m+n is 3, 4, or 5; with the proviso that a case where Am is piperidino, m is 3 and n is 1 is omitted), its pharmaceutically acceptable acid addition salts and quaternary ammonium salts. EXAMPLE:1-Methyl-4-piperidyl alpha-hexamethyleneimidophenylacetate dihydrochloride. USE:Having antispasmodic action with high acetylcholine resistance of a drug such as an antispasmodic, etc., furthermore having low side effect such as mydriasis, inhibition of spittle secretion, pulsus frequens, etc. PROCESS:A compound shown by the formula II (Hal is halogen such as Cl, Br, or I) or its acid addition salt is reacted with a compound shown by the formula H-Am, to give a compound shown by the formula I .
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EXAMPLE:1-Methyl-4-piperidyl alpha-hexamethyleneimidophenylacetate dihydrochloride. USE:Having antispasmodic action with high acetylcholine resistance of a drug such as an antispasmodic, etc., furthermore having low side effect such as mydriasis, inhibition of spittle secretion, pulsus frequens, etc. PROCESS:A compound shown by the formula II (Hal is halogen such as Cl, Br, or I) or its acid addition salt is reacted with a compound shown by the formula H-Am, to give a compound shown by the formula I .</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1983</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19831203&DB=EPODOC&CC=JP&NR=S58208270A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19831203&DB=EPODOC&CC=JP&NR=S58208270A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KADOKAWA TOSHIAKI</creatorcontrib><creatorcontrib>NISHIMURA ATSUKI</creatorcontrib><creatorcontrib>KAWASHIMA KATSUYOSHI</creatorcontrib><creatorcontrib>NARUTO SHIYUNSUKE</creatorcontrib><creatorcontrib>MIZUTA YASUYUKI</creatorcontrib><title>ALPHA-CYCLIC AMINOPHENYLACETIC ESTERS, THEIR ACID ADDITION SALTS AND QUATERNARY AMMONIUM SALTS</title><description>NEW MATERIAL:A compound shown by the formula I (R1 is H, halogen, OH, lower alkyl, CF3, or lower alkoxy; R2 is lower alkyl; Am is 5-9-membered cyclic amino group which may be replaced with lower alkyl; m and n are 1, 2, or 3, and m+n is 3, 4, or 5; with the proviso that a case where Am is piperidino, m is 3 and n is 1 is omitted), its pharmaceutically acceptable acid addition salts and quaternary ammonium salts. 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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	ALPHA-CYCLIC AMINOPHENYLACETIC ESTERS, THEIR ACID ADDITION SALTS AND QUATERNARY AMMONIUM SALTS
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