ANTIBIOTIC DC-81 AND ITS PREPARATION

NEW MATERIAL:An antibiotic DC-81 shown by the formula. USE:An antibacterial agent, and disinfectant. Having antibacterial activity and antitumor activity. PROCESS:A bacterium such as DC-81 strain (FERM-P 6502) belonging to the genus Streptomyces, capable of producing DC-81, is cultivated in a medium...

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Hauptverfasser:	TOMITA FUSAO, ASANO KOUZOU, MORIMOTO MAKOTO, TAMAOKI TATSUYA, FUJIMOTO KAZUHISA, KAWAMOTO ISAO, IMAI RIYOUJI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	NEW MATERIAL:An antibiotic DC-81 shown by the formula. USE:An antibacterial agent, and disinfectant. Having antibacterial activity and antitumor activity. PROCESS:A bacterium such as DC-81 strain (FERM-P 6502) belonging to the genus Streptomyces, capable of producing DC-81, is cultivated in a medium, DC- 81 is accumulated in the culture, and DC-81 shown by the formula is collected from the culture. Properly, the culture temperature is 25-40 deg.C, and the pH of the medium is 4-10. Having the following physical and chemical properties. Melting point: 98-105 deg.C, molecular weight: 246 (mass spectrum method), molecular formula: C13H14O3N2; specific rotatory power; [alpha] D=+135 deg. (c 0.2, methanol); solubility: easily soluble in DMSO, methanol, etc., soluble in ethyl acetate, and water, slightly soluble in ethyl ether, and n-hexane.