PREPARATION OF CARBOXYLIC ACID DERIVATIVE

PURPOSE:To prepare the titled substance useful as an intermediate of pharmaceuticals, etc., safely, in high yield, in one step , by using a magnesium complex of an acetoacetic acid lower alkyl ester as a raw material, and reacting with a 2,2-dimethylpropionic acid halide. CONSTITUTION:The objective...

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Bibliographische Detailangaben
Hauptverfasser:	SUENOBU YUKIKAZU, HANAYAMA NAOKI, MIURA TAKANORI, KASAGI MASAHIRO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE:To prepare the titled substance useful as an intermediate of pharmaceuticals, etc., safely, in high yield, in one step , by using a magnesium complex of an acetoacetic acid lower alkyl ester as a raw material, and reacting with a 2,2-dimethylpropionic acid halide. CONSTITUTION:The objective compound is prepared by reacting magnesium complex or calcium complex of an acetoacetic acid lower alkyl ester with a 2,2-dimethylpropionic acid halide in an inert solvent such as hexane. The amount of the complex is >=0.5mol, pref. 1.0-1.5mol/mol of the 2,2-dimethylpripionic acid halide. The complex can be prepared by reacting an acetoacetic acid lower alkyl ester with oxide or hydroxide of magnesium or calcium.