PURIFICATION OF COENZYME Q

PURPOSE:To purify the titled substance, by treating raw coenzyme Q containing ubichromenol as impurity with a trivalent iron, nickel, or cobalt compound so that ubichromenol is modified and removed. CONSTITUTION:A solution of raw coenzyme Q containing at least ubichromenol as impurity in a hydrophob...

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Bibliographische Detailangaben
Hauptverfasser: TAWARA TORAICHI, FURUSHIMA MASAKAZU, SHINNO ATSUYUKI
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:PURPOSE:To purify the titled substance, by treating raw coenzyme Q containing ubichromenol as impurity with a trivalent iron, nickel, or cobalt compound so that ubichromenol is modified and removed. CONSTITUTION:A solution of raw coenzyme Q containing at least ubichromenol as impurity in a hydrophobic solvent, e.g., n-hexane, heptane, ethyl ether, etc. is brought into contact with a trivalent iron, nickel or cobalt compound. The compound is hydrochloride, acetate, nitrate, etc. and the contact may be solid-liquid or liquid-liquid contact. By this contact, ubichromenol is modified, and modified ubichromenol is separated and removed by silica gel chromatography, etc.