NOVEL NUCLEOTIDE AND ITS PREPARATION

NEW MATERIAL:A compound shown by the formulaI(A is deoxyadenosyl residue; C is deoxycytidyl residue; T is thymidyl residue; P is a group shown by the formula). USE:A material for preparing a physiologically active substance having a contraction action on the smooth muscle of cholecyst and secretion...

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Bibliographische Detailangaben
Hauptverfasser:	TACHIBANA SHINROU, WAKABAYASHI TOSHIAKI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound shown by the formulaI(A is deoxyadenosyl residue; C is deoxycytidyl residue; T is thymidyl residue; P is a group shown by the formula). USE:A material for preparing a physiologically active substance having a contraction action on the smooth muscle of cholecyst and secretion action on the pancreatic enzyme by the technique of genetic engineering. PROCESS:A compound shown by the formula III (A deg. is N-benzoyldeoxyadenosyl residue; C deg. is N-benzoyldeoxycytidyl residue; P is a group shown by the formula IV; DMT is dimethoxytrityl which protects 5'-OH of nucleoside) is condensed with a compound shown by the formula V (Bz is benzoyl which protects 3'-OH of nucleoside), and all the protecting groups are eliminated, to give dodecanucleotide shown by the formulaI. The condensation is carried out in the presence of a condensation agent obtained by combining a group of mesitylene sulfonyltriazole, etc. with a group of 1-methylimidazole, etc.